Melatonin is the hormone that signals your body it's time to sleep — but a strong sleep signal doesn't help much if your mind is still racing when your head hits the pillow. That's the problem this formula was built for.

Natrol Advanced Sleep Melatonin+ 5-HTP is Natrol's most advanced sleep formula, addressing the three most common sleep concerns: a racing mind, difficulty falling asleep, and difficulty sleeping through the night. Its bi-layer tablet releases each ingredient at the optimal time — one layer immediately releases 5-HTP and melatonin to help you relax and fall asleep, while the second layer delivers controlled-release melatonin to support sleep through the night. Each tablet also provides vitamin B6, which supports the body's own melatonin production. 100% drug-free and non-habit forming.

• Addresses a racing mind, difficulty falling asleep and difficulty staying asleep
• 50mg of 5-HTP to help calm your mind
• Immediate-release melatonin to help you fall asleep faster
• Controlled-release melatonin layer to help you sleep through the night
• With vitamin B6 to support natural melatonin production
• 100% drug-free and non-habit forming

If you take any medication — particularly anything affecting mood or serotonin — consult your healthcare professional before use. For the nights when it's your thoughts keeping you awake, this is the formula designed for the whole problem.

What does 5-HTP add to a melatonin sleep formula?

5-HTP (5-hydroxytryptophan) is a naturally occurring compound the body uses to produce serotonin, which is itself the precursor to melatonin. In this formula, 50mg of 5-HTP is included in the immediate-release layer to help calm a racing mind while the melatonin builds the sleep signal — targeting the mental wind-down that melatonin alone doesn't address.

How does the bi-layer tablet work?

The tablet has two layers that dissolve at different speeds. The first layer releases 5-HTP and melatonin immediately, supporting relaxation and sleep onset. The second layer releases melatonin gradually through the night, supporting sustained sleep rather than a single dose that wears off.

Who is Advanced Sleep Melatonin+ 5-HTP for?

It suits adults whose sleeplessness has a mental component — lying awake with a busy mind — as well as trouble falling or staying asleep. If your only issue is drifting off, a standard or fast dissolve melatonin may be all you need; this formula targets the full picture.

How do you take Natrol Advanced Sleep Melatonin+ 5-HTP?

Take 1 tablet 20 minutes before bedtime. Plan for a full night's sleep, and avoid taking it before driving or operating machinery.

Can I take 5-HTP with other medications?

Speak with your healthcare professional first — particularly if you take tranquilisers, sedatives, or medication for depressive or autoimmune conditions, as the label advises. 5-HTP is involved in serotonin production, so professional guidance matters more here than with plain melatonin.

Package Description: 60 Bi-Layer Tablets

Serving Size: 1 Tablet

Number of Servings: 60

Other Ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Hypromellose, Cellulose Gum, Silicon Dioxide, Stearic Acid, Maltodextrin, Beet Root Powder, Magnesium Stearate, Methylcellulose, Glycerin.

No: Milk, egg, fish, wheat, crustacean shellfish, tree nuts, peanuts, soy, yeast, artificial colors, flavors or preservatives.

Take 1 tablet 20 minutes before bedtime.

If you are under medical supervision or using any tranquilizers or sedatives, seek the advice of your healthcare professional prior to using. Consult your healthcare professional prior to use if you have an autoimmune condition, depressive disorder or are pregnant or lactating. Not for use by children under 12 years of age. Do not take when operating machinery or driving a vehicle. People with allergies to soy, wheat, or corn should consult their healthcare professional before taking this product.

Storage: Keep tightly closed in a dry place at room temperature (59-77 degrees F). Keep out of reach of children.